Total number of library items: 251

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Published Year: 2010.    Publication Type: Journal Article
Publication Title: Cancer Epidemiology, Biomarkers & Prevention.

A Clinical Laboratory Model for Evaluating the Acute Effects of Electronic “Cigarettes”: Nicotine Delivery Profile and Cardiovascular and Subjective Effects

Authors: Eissenberg, Thomas E., Vansickel, Andrea R., Cobb, Caroline O., Weaver, Michael F.

1055-9965, 1538-7755.    DOI: 10.1158/1055-9965.EPI-10-0288.


Electronic “cigarettes” are marketed to tobacco users as potential reduced exposure products (PREP), albeit with little information regarding electronic cigarette user toxicant exposure and effects. This information may be obtained by adapting clinical laboratory methods used to evaluate other PREPs for smokers.

Thirty-two smokers participated in four independent Latin-square ordered conditions that differed by product: own brand cigarette, “NPRO” electronic cigarettes (NPRO EC; 18 mg cartridge), “Hydro” electronic cigarettes (Hydro EC; 16 mg cartridge), or sham (unlit cigarette). Participants took 10 puffs at two separate times during each session. Plasma nicotine and carbon monoxide (CO) concentration, heart rate, and subjective effects were assessed.

Own brand significantly increased plasma nicotine and CO concentration and heart rate within the first five minutes of administration whereas NPRO EC, Hydro EC, and sham smoking did not. Own brand, NPRO EC, and Hydro EC (but not sham) significantly decreased tobacco abstinence symptom ratings and increased product acceptability ratings. The magnitude of symptom suppression and increased acceptability was greater for own brand than for NPRO EC and Hydro EC.

Under these acute testing conditions, neither of the electronic cigarettes exposed users to measurable levels of nicotine or CO, although both suppressed nicotine/tobacco abstinence symptom ratings.

Tag: Cardiovascular, Biomarkers

Published Year: 2010.    Publication Type: Journal Article
Publication Title: BMC Public Health.

Electronic cigarettes: a survey of users


1471-2458.    DOI: 10.1186/1471-2458-10-231.


Background Little is known about users of electronic cigarettes, or their opinions, satisfaction or how and why they use such products. Methods An internet survey of 81 ever-users of ecigarettes in 2009. Participants answered open-ended questions on use of, and opinions about, ecigarettes. Results Respondents (73 current and 8 former users) lived in France, Canada, Belgium or Switzerland. Most respondents (77%) were men; 63% were former smokers and 37% were current smokers. They had used e-cigarettes for 100 days (median) and drew 175 puffs per day (median). Participants used the ecigarette either to quit smoking (53 comments), to reduce their cigarette consumption (14 comments), in order not to disturb other people with smoke (20 comments), or in smoke-free places (21 comments). Positive effects reported with ecigarettes included their usefulness to quit smoking, and the benefits of abstinence from smoking (less coughing, improved breathing, better physical fitness). Respondents also enjoyed the flavour of ecigarettes and the sensation of inhalation. Side effects included dryness of the mouth and throat. Respondents complained about the frequent technical failures of ecigarettes and had some concerns about the possible toxicity of the devices and about their future legal status. Conclusions Ecigarettes were used mainly to quit smoking, and may be helpful for this purpose, but several respondents were concerned about potential toxicity. There are very few published studies on ecigarettes and research is urgently required, particularly on the efficacy and toxicity of these devices.


Published Year: .    Publication Type: Blog Post
Publication Title:

Vape Shop Air Sampling by California State Health Department Suggests that Secondhand Vape Exposure is Minimal

Authors: Siegel, Michael

.    DOI: .


As part of its investigation into the potential health effects of electronic cigarettes, the California Department of Public Health has been conducting air sampling and personal exposure monitoring in vape shops throughout the state. The results of sampling in one of these vape shops, obtained by The Rest of the Story, reveal that “secondhand vaping” appears to result in minimal exposure of bystanders to hazardous chemicals. In this particular vape shop, sampling was conducted under quite adverse conditions. Many of the employees vaped throughout the sampling and 13 customers vaped while in the shop. There was no active ventilation system, and visible clouds of vapor were visible at times. So this seems to represent a high level of exposure compared to what one might expect in a public place outside a vape shop (e.g., a restaurant, bar, or office workplace). Here are the major results of the air sampling: Nicotine: Not detected Glycidol: Not detected Formaldehyde: 7.2 ppb Diacetyl: Not detected using standard method 2,3-Pentanedione: Not detected using standard method Acetyl butyryl: Not detected using standard method Acetoin: Not detected using standard method Acetone: Not detected Ethyl benzene: Not detected m,p-Xylene: Not detected o-Xylene: Not detected Toluene: Not detected Acetaldehyde: Not detected Acetonitrile: Not detected alpha-pinene: Not detected Benzene: Not detected Chloroform: Not detected d-Limonene: Not detected Methylene chloride: Not detected Methyl methacrylate: Not detected n-Hexane: Not detected Styrene: Not detected The level of formaldehyde detected is consistent with normal indoor and outdoor air levels of formaldehyde under baseline conditions. Other than the small concentration of formaldehyde, the only other chemicals that were quantified were ethanol (alcohol) and isopropyl alcohol.

Tag: Second Hand Exposure